...” All this and more to the sameeffect the landlady delivered with great irritation, and her good maidMaritornes backed her up, while the daughter held her peace and smiledfrom time to time... 
Miguel de Cervantes 「The History of Don Quixote, Vol. I, Complete」
...His majesty scratched his head and sides and all parts of his body with much vehemence—a sign of great agitation within, if not irritation without, and replied in a long speech...
W.H.G. Kingston 「The Two Supercargoes」
...In many states the private gamepreserves are a source of great irritation, and many have beenattacked in courts of law...
William T. Hornaday 「Our Vanishing Wild Life」
...Hooker), observed the singular fact with an orchid, the Bonatea speciosa, the development of the ovarium could be effected by mechanical irritation of the stigma...
Charles Darwin 「The Variation of Animals and Plants Under Domestication, Vol. I.」
..., wear down the teeth; butthe stumps become sources of irritation, and often cause disease...
Dinks, Mayhew, and Hutchinson 「The Dog」
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